Once you have clearly defined your Home Page message, make sure that you give your potential customer "a call to action". This is something that incites your user to do something. It might be to click a button to link to another page, complete a sign-up form for a mail list, download information, or call a sales person. Giving your user a secondary message, or step to take, connects them to whatever your primary goal for your site may be.
Remember to ask yourself, "What is the one thing I want my end user to come away knowing about my website?" For example, on my Plain & Simple Web Design site, my home page makes it VERY clear that I provide inexpensive website design for $400. I repeat it several times and have a slide show that represents my work so that my customer knows exactly what I have to offer. I also have a "call to action" button that allows them to immediately make their website deposit right on the homepage!
You've only got one chance at a first impression. Make it count!